Granular cell tumour of cecum mimicking a neuroendocrine tumor

Abstract

Granular cell tumor (GCT) is a benign soft tissue neoplasm generally believed to be of nerve sheath origin. It is most frequently seen in skin, subcutaneous tissue and oral cavity. GCTs are uncommon in gastrointestinal tract (GIT), in which the majority are located in the esophagus. In this article, we report a case of GCT involving cecum in a 22 years lady. She had a sessile polyp in the cecum which was thought to be NET. Typical histomorphology and expression of S-100 on immunohistochemistry confirmed the diagnosis.We have reviewed, the GCTs of cecum reported previously with emphasis on the differential diagnosis. To best of our knowledge, this is only the 3 case of GCT of cecum reported in the Indian literature. Colonic GCTs are extremely uncommon. This is just the third case of GCT of colon in Indian literature. GCTs pose a diagnostic challenge due to lack of symptoms or nonspecific symptoms. Awareness of this entity helps in preventing misdiagnosis as happened in this case and avoiding further unnecessary treatment.