Role of metabolomics in advancing precision medicine and personalized nutrition: A systematic review of clinical applications and future prospects

Abstract

Metabolomics, the comprehensive study of small molecules in biological systems, has emerged as a powerful tool in advancing precision medicine and personalized nutrition. This systematic review aims to evaluate the current clinical applications and future prospects of metabolomics in these fields. We searched PubMed, Scopus, and Web of Science databases for relevant studies published between 2010 and 2024. Out of 1,500 initially identified studies, 120 met our inclusion criteria. Our analysis revealed that metabolomics has significantly contributed to biomarker discovery, patient stratification, and treatment response prediction in various diseases, particularly in oncology and cardiology. In nutrition, metabolomics has enabled more accurate dietary intake assessment and personalized nutritional recommendations. Despite challenges in standardization and data interpretation, the integration of metabolomics with other omics technologies shows promise for revolutionizing healthcare and nutrition practices.