Affiliation:
1. Technical University of Munich, Munich, Germany
2. National Tsing Hua University, Hsinchu, Taiwan
3. Fuzhou University, Fuzhou, China
4. Duke University, Durham, USA
Abstract
As one of the most promising lab-on-a-chip systems, flow-based microfluidic biochips are being increasingly used for automatically executing various laboratory procedures in biology and biochemistry, such as enzyme-linked immunosorbent assay, point-of-care diagnosis, and so on. As manufacturing technology advances, the characteristic dimensions of biochip systems keep shrinking, and tens of thousands of microvalves can now be integrated into a coin-sized microfluidic platform, making the conventional manual-based chip design no longer applicable. Accordingly, computer-aided design (CAD) of microfluidics has attracted considerable research interest in the EDA community over the past decade. This review article presents recent advances in the design automation of biochips, involving CAD techniques for architectural synthesis, wash optimization, testing, fault diagnosis, and fault-tolerant design. With the help of these CAD tools, chip designers can be released from the burden of complex, large-scale design tasks. Meanwhile, new chip architectures can be explored automatically to open new doors to meet requirements from future large-scale biological experiments and medical diagnosis. We discuss key trends and directions for future research that are related to enable microfluidics to reach its full potential, thus further advancing the development and progression of the microfluidics industry.
Funder
Technical University of Munich–Institute for Advanced Study
Natural Science Foundation of Fujian Province
Humboldt Research Fellowship from the Alexander von Humboldt Foundation
National Natural Science Foundation of China
Foundation of Ministry of Science and Technology
Deutsche Forschungsgemeinschaft (DFG) through TUM International Graduate School of Science and Engineering
National Science Foundation
German Excellence Initiative and the European Union Seventh Framework Programme
TUM University Foundation Fellowship from Technical University of Munich
Publisher
Association for Computing Machinery (ACM)
Subject
General Computer Science,Theoretical Computer Science
Cited by
25 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献