1. Resarch Group of Oral Health Sciences, Faculty of Medicine, University of Oulu, and Oulu University Hospital, P.O. Box 8000, Oulu 90014, Finland
2. Medical Research Center Oulu, Oulu University Hospital, P.O. Box 5000, Oulu 90029, Finland
3. *Contributed equally
4. Institute of Dentistry, University of Eastern Finland, Kuopio campus, and Educational Dental Clinic, Kuopio University Hospital, P.O. Box 1627, Kuopio 70211, Finland
5. Amsterdam UMC and Academic Centre for Dentistry Amsterdam(ACTA), Vrije Universiteit Amsterdam, Departmentof Oral and Maxillofacial Surgery/Oral Pathology, De Boelelaan 1117, Amsterdam, The Netherlands
6. SIB Labs, University of Eastern Finland, P.O. Box 1627, Kuopio 70211, Finland