Clopidogrel Use in <i>CYP2C19</i> Loss-of-Function Carriers With High Bleeding Risk After Percutaneous Coronary Intervention

Author:

Sawayama Yuichi1,Tomita Yukinori2,Kohyama Soji1,Higo Yosuke1,Kodama Kenji1,Asada Kohei1,Yagi Noriaki1,Fukuyama Megumi1,Hayashi Atsushi1,Shioyama Wataru1,Sakai Hiroshi1,Ozawa Tomoya1,Isono Tetsuichiro3,Hira Daiki3,Yamamoto Takashi4,Morita Shin-ya3,Nakagawa Yoshihisa1

Affiliation:

1. Department of Cardiovascular Medicine, Shiga University of Medical Science

2. Department of Cardiovascular Medicine, Toyosato Hospital

3. Department of Pharmacy, Shiga University of Medical Science Hospital

4. Department of Cardiovascular Medicine, Kohka Public Hospital

Publisher

Japanese Circulation Society

Subject

Cardiology and Cardiovascular Medicine,General Medicine

Reference30 articles.

1. 1. Mega JL, Close SL, Wiviott SD, Shen L, Hockett RD, Brandt JT, et al. Cytochrome P-450 polymorphisms and response to clopidogrel. N Eng J Med 2009; 360: 354–362, doi:10.1056/nejmoa0809171.

2. 2. Wallentin L, James S, Storey RF, Armstrong M, Barratt BJ, Horrow J, et al. Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: A genetic substudy of the PLATO trial. Lancet 2010; 376: 1320–1328, doi:10.1016/s0140-6736(10)61274-3.

3. 3. Ogawa H, Isshiki T, Kimura T, Yokoi H, Nanto S, Takayama M, et al. Effects of CYP2C19 allelic variants on inhibition of platelet aggregation and major adverse cardiovascular events in Japanese patients with acute coronary syndrome: The PRASFIT-ACS study. J Cardiol 2016; 68: 29–36, doi:10.1016/j.jjcc.2015.07.019.

4. 4. Pereira NL, Rihal C, Lennon R, Marcus G, Shrivastava S, Bell MR, et al. Effect of CYP2C19 genotype on ischemic outcomes during oral P2Y12 inhibitor therapy: A meta-analysis. JACC Cardiovasc Interv 2021; 14: 739–750, doi:10.1016/j.jcin.2021.01.024.

5. 5. Holmes DR Jr, Dehmer GJ, Kaul S, Leifer D, O’Gara PT, Stein CM. ACCF/AHA clopidogrel clinical alert: Approaches to the FDA “boxed warning”: A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the American Heart Association endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. J Am Coll Cardiol 2010; 56: 321–341, doi:10.1016/j.jacc.2010.05.013.

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