Statistical analysis of predictors of the effectiveness of complex therapy in patients with skin scarring

Author:

Kazantseva. K. V.1ORCID,Frolkov V. K.2ORCID,Nagornev S. N.2ORCID,Gusakova E. V.3ORCID,Nagorneva M. S.4ORCID

Affiliation:

1. Limited Liability Company «Skin Art», Moscow, Russia

2. FSBI Center for Strategic Planning and Management of Medical and Biological Health Risks of the Federal Medical and Biological Agency of the Russian Federation, Moscow, Russia

3. FSBI FPE Central State Medical Academy of the Presidential Administration of the Russian Federation

4. FSAEI HE Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Abstract

The variation of indicators that characterize skin scarring increases in patients with metabolic syndrome, which may affect the effectiveness of therapeutic measures. It has been found that pathological processes in the skin scar in the initial state correlate to the greatest extent with the index of insulin resistance, the atherogenic coefficient and the coefficient of antioxidant protection. It is proved that the effectiveness of complex physiotherapy with the addition of the internal intake of medium-mineralized water «Essentuki №17» directly correlates with an increase in tissue sensitivity to insulin and the activation of antioxidant enzymes, as well as with a decrease in dyslipidemia. Linear regression equations are presented to determine significant predictors of treatment effectiveness, which can lead to the creation of individualized therapeutic programs using preformed and natural physical factors.

Publisher

PANORAMA Publishing House

Reference12 articles.

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3. Kazantseva K.V., Nagornev S.N., Frolkov V.K. Fizioterapiia rubtsovykh izmenenii kozhi v usloviiakh metabolicheskogo sindroma [Physiotherapy of cicatricial changes in the skin in conditions of metabolic syndrome] // Fizioterapevt [Physiotherapist] . 2020; 6: 15–21 (In Russ.)

4. Iliin M.V. Sochetannoe primenenie ultrafonoforeza proteoliticheskikh kollagenaz i metodiki fraktsionnogo fototermoliza v korrektsii rubtsovykh izmenenii kozhi. Avtoref. diss. kand. med. nauk [Combined application of ultraphonophoresis of proteolytic collagenases and fractional photothermolysis in the correction of cicatricial changes in the skin. Abstract of thesis for the degree of PhD Candidate in Medicine], M., 2014. 24 p. (In Russ.)

5. Kazantseva K.V., Nagornev S.N., Frolkov V.K., Gusakova E.V. Dinamika pokazatelei perekisnogo metabolizma u patsientov s rubtsovymi deformatsiiami kozhi v sochetanii s metabolicheskim sindromom pri kompleksnom primenenii fizioterapevticheskikh metodov lecheniia i pitievykh mineralnykh vod [Dynamics of indicators of peroxide metabolism in patients with cicatricial deformities of the skin in combination with metabolic syndrome with the combined use of physiotherapeutic methods of treatment and drinking mineral waters] // Fizioterapevt [Physiotherapist]. 2021; 2: 46–57. (In Russ.)

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