L-Phys

Abstract

L-Phys - Mar 1-15, 2016. (unmoderated session: Mar 16-25, 2016) Physiopathology of Lymphedema Moderator: Dr. Fausto Passariello Discussant: Prof. Waldemar Lech Olszewski Lymphedema of lower and upper limbs is a consequence of irreversible interruption of lymphatic collectors draining skin, subcutaneous tissue, fascia and to lesser extent other tissues. There are two major groups of lymphedema: post-inflammatory caused by bacterial and viral infections (post-dermatitis) and postsurgical after lymphadenectomy and radiotherapy in cancer (after mastectomy, histerectomy, skin tumors-melanoma). This last type is increasing in number due to prolonged longevity after anti-cancer therapy. The number of patients with lymphedema of limbs reaches now, according to WHO, 300 million. The general knowledge of the anatomy and function of the lymphatic system is still rudimentary. This system serves maintenance of cell fluid and chemical environment, transport of synthetized functional proteins and removal of waste products and cellular debris. Dendritic cells and recirculating lymphocytes play a dominant role in recognition and elimination of penetrating microorganisms. Our discussion on Vasculab should be directed more to questions than comments. The product may be more educational than instructive but provide a basis for rational modern therapy. The main points for discussion are: - Mechanism of plasma capillary filtration and lymph formation - Transport of capillary filtrate (tissue fluid/lymph) to blood circulation - Contemporary methods of conservative and surgical therapy.