Author:
Sawant Anuradha,Garland S. Jayne,House Andrew A.,Overend Tom J.
Abstract
Purpose: Fatigue is one of the most frequent debilitating symptoms reported by people with end-stage renal disease (ESRD) on haemodialysis (HD) therapy. A wide range of underlying abnormalities, including skeletal muscle weakness, have been implicated as causes of this fatigue. Skeletal muscle weakness is well established in this population, and such muscle weakness is amenable to physical therapy treatment. The purpose of this review was to identify morphological, electrophysiological, and metabolic characteristics of skeletal muscles in people with ESRD/HD that may cause skeletal muscle weakness. Method: Electronic databases were searched for relevant literature from inception to March 2010. Inclusion criteria were English language; adult subjects with ESRD/HD; and the use of muscle biopsy, electromyography, and nuclear magnetic spectroscopy (31P-NMRS) techniques to evaluate muscle characteristics. Results: In total, 38 studies were included. All studies of morphological characteristics reported type II fibre atrophy. Electrophysiological characteristics included both neuropathic and myopathic skeletal muscle changes. Studies of metabolic characteristics revealed higher cytosolic inorganic phosphate levels and reduced effective muscle mass. Conclusion: The results indicate an array of changes in the morphological, electrophysiological, and metabolic characteristics of skeletal muscle structure in people with ESRD/HD that may lead to muscle weakness.
Publisher
University of Toronto Press Inc. (UTPress)
Subject
Physical Therapy, Sports Therapy and Rehabilitation
Reference73 articles.
1. Canadian Institute for Health Information (2010).Treatment of end-stage organ failure in Canada, 1999 to 2008—CORR 2010 annual report.Ottawa:The Institute
2. Exercise in the End-Stage Renal Disease Population
3. Kidney Transplant [homepage on the Internet].Available from: http://www.kidney.org/atoz/content/kidneytransnewlease.cfm
4. Skeletal muscle morphology and capillarization of renal failure patients receiving different dialysis therapies
5. Hypercatabolism in dialysis patients
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