Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohort-Reference-Cited by-同舟云学术

Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohort

Published:2022-10-10 Issue:1 Volume:32 Page:105-113
ISSN:1055-9965
Container-title:Cancer Epidemiology, Biomarkers & Prevention
language:en
Short-container-title:

Author:

Hvidtfeldt Ulla Arthur¹^ORCID,Chen Jie²^ORCID,Rodopoulou Sophia³^ORCID,Strak Maciej⁴⁵^ORCID,de Hoogh Kees⁶^ORCID,Andersen Zorana J.⁷^ORCID,Bellander Tom⁸⁹^ORCID,Brandt Jørgen¹⁰¹¹^ORCID,Fecht Daniela¹²^ORCID,Forastiere Francesco¹³¹⁴^ORCID,Gulliver John¹⁵¹⁶^ORCID,Hertel Ole¹⁷^ORCID,Hoffmann Barbara H.¹⁸^ORCID,Katsouyanni Klea³¹⁵^ORCID,Ketzel Matthias¹⁰¹⁹^ORCID,Brynedal Boel²⁰^ORCID,Leander Karin⁸^ORCID,Ljungman Petter L.S.⁸²¹^ORCID,Magnusson Patrik K.E.²²^ORCID,Nagel Gabriele²³^ORCID,Pershagen Göran⁸⁹^ORCID,Rizzuto Debora²⁴²⁵^ORCID,Boutron-Ruault Marie-Christine²⁶^ORCID,Samoli Evangelia³^ORCID,So Rina⁷^ORCID,Stafoggia Massimo⁸¹³^ORCID,Tjønneland Anne¹⁷^ORCID,Vermeulen Roel²⁷^ORCID,Verschuren W.M. Monique⁵²⁷^ORCID,Weinmayr Gudrun²³,Wolf Kathrin²⁸^ORCID,Zhang Jiawei⁷^ORCID,Zitt Emanuel²⁹³⁰^ORCID,Brunekreef Bert²^ORCID,Hoek Gerard²,Raaschou-Nielsen Ole¹¹⁰^ORCID

Affiliation:

1. 1Danish Cancer Society Research Center, Copenhagen, Denmark.

2. 2Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.

3. 3Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

4. 4Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.

5. 5National Institute for Public Health and the Environment, Bilthoven, the Netherlands.

6. 6Swiss Tropical and Public Health Institute and University of Basel, Basel, Switzerland.

7. 7Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

8. 8Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

9. 9Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden.

10. 10Department of Environmental Science, Aarhus University, Roskilde, Denmark.

11. 11iClimate – interdisciplinary Centre for Climate Change, Aarhus University, Roskilde, Denmark.

12. 12MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom.

13. 13Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, Rome, Italy.

14. 14Environmental Research Group, School of Public Health, Faculty of Medicine, Imperial College, London, United Kingdom.

15. 15MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom.

16. 16Centre for Environmental Health and Sustainability & School of Geography, Geology and the Environment, University of Leicester, Leicester, United Kingdom.

17. 17Departments of Ecoscience, Aarhus University, Roskilde, Denmark.

18. 18Institute for Occupational, Social and Environmental Medicine, Centre for Health and Society, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

19. 19Global Centre for Clean Air Research (GCARE), University of Surrey, Guildford, United Kingdom.

20. 20Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.

21. 21Department of Cardiology, Danderyd University Hospital, Stockholm, Sweden.

22. 22Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

23. 23Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.

24. 24Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.

25. 25Stockholm Gerontology Research Center, Stockholm, Sweden.

26. 26University Paris-Saclay, UVSQ, Inserm, Gustave Roussy, “Exposome and Heredity” team, CESP UMR1018, Villejuif, France.

27. 27Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

28. 28Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.

29. 29Agency for Preventive and Social Medicine (aks), Bregenz, Austria.

30. 30Department of Internal Medicine 3, LKH Feldkirch, Feldkirch, Austria.

Abstract

Abstract Background: Established risk factors for breast cancer include genetic disposition, reproductive factors, hormone therapy, and lifestyle-related factors such as alcohol consumption, physical inactivity, smoking, and obesity. More recently a role of environmental exposures, including air pollution, has also been suggested. The aim of this study, was to investigate the relationship between long-term air pollution exposure and breast cancer incidence. Methods: We conducted a pooled analysis among six European cohorts (n = 199,719) on the association between long-term residential levels of ambient nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), and ozone in the warm season (O3) and breast cancer incidence in women. The selected cohorts represented the lower range of air pollutant concentrations in Europe. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. Results: During 3,592,885 person-years of follow-up, we observed a total of 9,659 incident breast cancer cases. The results of the fully adjusted linear analyses showed a HR (95% confidence interval) of 1.03 (1.00–1.06) per 10 μg/m³ NO2, 1.06 (1.01–1.11) per 5 μg/m³ PM2.5, 1.03 (0.99–1.06) per 0.5 10−5 m−1 BC, and 0.98 (0.94–1.01) per 10 μg/m³ O3. The effect estimates were most pronounced in the group of middle-aged women (50–54 years) and among never smokers. Conclusions: The results were in support of an association between especially PM2.5 and breast cancer. Impact: The findings of this study suggest a role of exposure to NO2, PM2.5, and BC in development of breast cancer.

Funder

Health Effects Institute

Publisher

American Association for Cancer Research (AACR)

Subject

Oncology,Epidemiology

Link

https://aacrjournals.org/cebp/article-pdf/doi/10.1158/1055-9965.EPI-22-0720/3213249/epi-22-0720.pdf

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