Associations of Race and Ethnicity with Hepatocellular Carcinoma, Decompensation, and Mortality in US Veterans with Cirrhosis

Author:

VoPham Trang12ORCID,Cravero Anne3ORCID,Feld Lauren D.4ORCID,Green Pamela5ORCID,Feng Ziding6ORCID,Berry Kristin5ORCID,Kim Nicole J.4ORCID,Vutien Philip4ORCID,Mendoza Jason A.789ORCID,Ioannou George N.14ORCID

Affiliation:

1. 1Epidemiology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.

2. 2Department of Epidemiology, University of Washington, Seattle, Washington.

3. 3Department of Medicine, University of Washington, Seattle, Washington.

4. 4Division of Gastroenterology, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington.

5. 5Research and Development, Veterans Affairs Puget Sound Health Care System, Seattle, Washington.

6. 6Biostatistics Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.

7. 7Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, Washington.

8. 8Department of Pediatrics and Nutritional Sciences Program, University of Washington, Seattle, Washington.

9. 9Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.

Abstract

Abstract Background: Among patients with cirrhosis, it remains unclear whether there are racial/ethnic differences in cirrhosis complications and mortality. We examined the associations between race/ethnicity and risk for hepatocellular carcinoma (HCC), cirrhosis decompensation, and all-cause mortality overall and by cirrhosis etiology. Methods: US Veterans diagnosed with cirrhosis from 2001 to 2014 (n = 120,992), due to hepatitis C virus (HCV; n = 55,814), alcohol-associated liver disease (ALD; n = 36,323), hepatitis B virus (HBV; n = 1,972), nonalcoholic fatty liver disease (NAFLD; n = 17,789), or other (n = 9,094), were followed through 2020 for incident HCC (n = 10,242), cirrhosis decompensation (n = 27,887), and mortality (n = 81,441). Multivariable Cox proportional hazards regression was used to estimate adjusted hazard ratios (aHR) and 95% confidence intervals (CI). Results: Compared with non-Hispanic White patients, Hispanic patients had higher risk for HCC overall (aHR, 1.32; 95% CI, 1.24–1.41) and by cirrhosis etiology, particularly for ALD- (aHR, 1.63; 95% CI, 1.42–1.87) and NAFLD-cirrhosis (aHR, 1.76; 95% CI, 1.41–2.20), whereas non-Hispanic Black patients had lower HCC risk in ALD- (aHR, 0.79; 95% CI, 0.63–0.98) and NAFLD-cirrhosis (aHR, 0.54; 95% CI, 0.33–0.89). Asian patients had higher HCC risk (aHR, 1.70; 95% CI, 1.29–2.23), driven by HCV- and HBV-cirrhosis. Non-Hispanic Black patients had lower risk for cirrhosis decompensation overall (aHR, 0.71; 95% CI, 0.68–0.74) and by cirrhosis etiology. There was lower risk for mortality among all other racial/ethnic groups compared with non-Hispanic White patients. Conclusions: Race/ethnicity is an important predictor for risk of developing HCC, decompensation, and mortality. Impact: Future research should examine factors underlying these racial/ethnic differences to inform prevention, screening, and treatment for patients with cirrhosis.

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

National Cancer Institute

U.S. Department of Veterans Affairs

Publisher

American Association for Cancer Research (AACR)

Subject

Oncology,Epidemiology

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