Antibody–Drug Conjugates: Advancing from Magic Bullet to Biological Missile-Reference-Cited by-同舟云学术

Antibody–Drug Conjugates: Advancing from Magic Bullet to Biological Missile

Published:2024-02-02 Issue:8 Volume:30 Page:1434-1437
ISSN:1078-0432
Container-title:Clinical Cancer Research
language:en
Short-container-title:

Author:

Veneziani Ana C.¹^ORCID,Sneha Suku¹^ORCID,Oza Amit M.¹²^ORCID

Affiliation:

1. 1Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

2. 2Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Abstract

Summary Precision drug development is focusing on targeting tumor cell surface proteins for therapeutic delivery, maximizing biomarker identified on-target damage to the tumor while minimizing toxicity. A recent article demonstrated high expression of B7-H4 antigen on resistant ovarian cancer cells and described preclinical activity of B7-H4–directed antibody–drug conjugate. See related article by Gitto et al., p. 1567

Funder

Princess Margaret Cancer Foundation

Publisher

American Association for Cancer Research (AACR)

Link

https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-23-3414/3413322/ccr-23-3414.pdf

Reference19 articles.

1. A B7-H4 targeting antibody-drug conjugate shows anti-tumor activity in PARPi and platinum resistant cancers with B7-H4 expression;Gitto;Clin Cancer Res,2024

2. Optimizing the safety of antibody–drug conjugates for patients with solid tumours;Tarantino,2023

3. The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research;Cheever;Clin Cancer Res,2009

4. Design and preclinical evaluation of a novel B7-H4-directed antibody-drug conjugate, AZD8205, alone and in combination with the PARP1-selective inhibitor AZD5305;Kinneer;Clin Cancer Res,2023

5. Immune therapy opportunities in ovarian cancer;Kandalaft;Am Soc Clin Oncol Educ Book,2020

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Epidermal Growth Factor Receptor Targeting in Colorectal Carcinoma: Antibodies and Patient-Derived Organoids as a Smart Model to Study Therapy Resistance;International Journal of Molecular Sciences;2024-06-28