Viewing RCC with a DNA Methylation Lens ENHANCES Understanding of ICI Resistance-Reference-Cited by-同舟云学术

Viewing RCC with a DNA Methylation Lens ENHANCES Understanding of ICI Resistance

Published:2023-01-26 Issue:7 Volume:29 Page:1170-1172
ISSN:1078-0432
Container-title:Clinical Cancer Research
language:en
Short-container-title:

Author:

Zhou Mi¹^ORCID,Kim William Y.¹²³⁴^ORCID

Affiliation:

1. 1Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina.

2. 2Department of Medicine, Division of Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

3. 3Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

4. 4Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Abstract

SummaryClear-cell renal cell carcinoma tumors with an enhancer demethylator phenotype (TED) harbor a worse prognosis and derive less clinical benefit from immunotherapy. The TED phenotype may help predict immunotherapy resistance.See related article by Lu et al., p. 1279

Funder

Kidney Cancer Association

National Institutes of Health

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

Link

https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-22-3574/3264477/ccr-22-3574.pdf

Reference15 articles.

1. An enhancer demethylator phenotype converged to immune dysfunction and resistance to immune checkpoint inhibitors in clear-cell renal cell carcinomas;Lu;Clin Cancer Res,2023

2. Comprehensive molecular characterization of clear-cell renal cell carcinoma;Creighton;Nature,2013

3. Integrated molecular analysis of clear-cell renal cell carcinoma;Sato;Nat Genet,2013

4. DNA methylation–based immune response signature improves patient diagnosis in multiple cancers;Jeschke;J Clin Invest,2017

5. Signatures of T-cell dysfunction and exclusion predict cancer immunotherapy response;Jiang;Nat Med,2018

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1. Silencing of genes by promoter hypermethylation shapes tumor microenvironment and resistance to immunotherapy in clear-cell renal cell carcinomas;Cell Reports Medicine;2023-11