New Frontiers in Translational Research in Neuro-oncology and the Blood-Brain Barrier: Report of the Tenth Annual Blood-Brain Barrier Disruption Consortium Meeting

Author:

Doolittle Nancy D.1,Abrey Lauren E.2,Bleyer W. Archie3,Brem Steven4,Davis Thomas P.5,Dore-Duffy Paula6,Drewes Lester R.7,Hall Walter A.8,Hoffman John M.9,Korfel Agnieszka10,Martuza Robert11,Muldoon Leslie L.1,Peereboom David12,Peterson Darryl R.13,Rabkin Samuel D.14,Smith Quentin15,Stevens Glen H.J.16,Neuwelt Edward A.1

Affiliation:

1. 1Department of Neurology, Oregon Health & Science University, Portland, Oregon;

2. 2Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York;

3. 3Divisions of Pediatrics and Community Oncology, M.D. Anderson Cancer Center, Houston, Texas;

4. 4Department of Neuro-oncology and Neurosurgery, H. Lee Moffitt Cancer Center, Tampa, Florida;

5. 5Department of Pharmacology, Program in Neurosciences and Physiological Sciences, University of Arizona Medical School, Tucson, Arizona;

6. 6Department of Neurology, Wayne State University, Detroit, Michigan;

7. 7Department of Biochemistry and Molecular Biology, University of Minnesota School of Medicine, Duluth, Minnesota;

8. 8Department of Neurosurgery, University of Minnesota, Minneapolis, Minnesota;

9. 9National Cancer Institute, Cancer Imaging Program, Bethesda, Maryland;

10. 10Department of Hematology, Oncology, and Transfusion Medicine, Charite Campus Benjamin Franklin, Berlin, Germany;

11. 11Department of Neurosurgery, Massachusetts General Hospital Neurosurgical Service, Harvard Medical School, Boston, Massachusetts;

12. 12Department of Hematology and Medical Oncology and

13. 14Department of Physiology and Biophysics, Chicago Medical School, North Chicago, Illinois;

14. 15Department of Neurosurgery, Massachusetts General Hospital-East Molecular Neurosurgery Laboratory, Harvard Medical School, Charlestown, Massachusetts; and

15. 16Department of Pharmaceutical Sciences, Texas Tech, Amarillo, Texas

16. 13Adult Neuro-oncology Brain Tumor Institute, Cleveland Clinic Foundation, Cleveland, Ohio;

Abstract

Abstract The blood-brain barrier (BBB) presents a major obstacle to the treatment of malignant brain tumors and other central nervous system (CNS) diseases. For this reason, a meeting partially funded by an NIH R13 grant was convened to discuss recent advances and future directions in translational research in neuro-oncology and the BBB. Cell biology and transport across the BBB, delivery of agents to the CNS, neuroimaging, angiogenesis, immunotherapy, and gene therapy, as well as glioma, primary CNS lymphoma, and metastases to the CNS were discussed. Transport across the BBB relates to the neurovascular unit, which consists not only of endothelial cells but also of pericyte, glia, and neuronal elements.

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

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