Development of a Delayed-Type Hypersensitivity (DTH) Model in the Cynomolgus Monkey

Author:

Bouchez Caroline1,Gervais Fréderic1,Fleurance Renaud1,Palate Bernard1,Legrand Jean-Jacques1,Descotes Jacques2

Affiliation:

1. CiToxLaB France, BP 503, 27005 Evreux, France

2. Poison Center, 69003 Lyon, France

Publisher

Japanese Society of Toxicologic Pathology

Subject

Toxicology,Pathology and Forensic Medicine

Reference21 articles.

1. 1. ICH S8 guideline: Immunotoxicity studies for human pharmaceuticals. 2005. http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Safety/S8/Step4/S8_Guideline.pdf.

2. 2. Luster MI, Dean JH, and Boorman GA. Cell-mediated immunity and its application in toxicology.Environ Health Perspect.43: 31-36. 1982.

3. 3. Descotes J, Tedone R, and Evreux JC. Immunotoxicity screening of drugs and chemicals: value of contact hypersensitivity to picryl chloride in the mouse.Methods Find Exp Clin Pharmacol.7:303-305. 1985.

4. 4. Dietert RR, Bunn TL, and Lee JE. The delayed type hypersensitivity assay using protein and xenogeneic cell antigens.Methods Mol Biol.598:185-194. 2010.

5. 5. Smith MJ, and White KLJrEstablishment and comparison of delayed-type hypersensitivity models in the B6C3F1 mouse.J Immunotoxicol.7: 308-317. 2010.

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