Synthesis and biological evaluation of new hydrazide-Schiff bases

Abstract

<div><p>A new series of N-({5-(substituted aryl)-furan-2-yl}-methylidene)-hydrazides were synthesized with a new class of Schiff bases derived from the reaction of substituted phenyl-1-ketohydrazide <strong>2</strong> or 2-(4-chloro-3-methylaryloxy) acetohydrazide <strong>3</strong> with different 5-(substituted aryl)-2-furfuraldehyde (<strong>1a-k</strong>) to yield substituted N-({5-(substituted aryl)-furan-2-yl}-methylidene)-hydrazides-Schiff bases <strong>(4a-f, 4g-k)</strong>. The title compounds were subjected to <em>in vitro</em> antibacterial screening against Gram positive bacterial strains-<em> S. aureus</em>, <em>B. cereus</em>, <em>E. faecalis</em> and <em>S. epidermidis</em>, and Gram negative bacteria strains- <em>E. coli</em>, <em>S. typhi</em>, <em>S. dysenteriae</em>  and <em>K. pneumoniae</em>. The synthesized Schiff bases were also evaluated for their anthelmintic activity against two species of earthworms (<em>Pheritima posthuma</em> and <em>Perionyx excavates</em>). Some compounds have shown promising antibacterial and anthelmintic activities.</p></div>