Antioxidant and Antibacterial Activities of Salen-type Schiff Base and Metal Complexes

Abstract

2-Aminobenzylamine based unsymmetrical salen type Schiff base and its Cu(II), Ni(II),Co(II) and Fe(III) metal complexes were researched in terms of their antioxidant and antibacterial activities in this study. 1,1-Diphenyl-2-picrylhydrazyl radical scavenging (DPPH) method, ferric reducing antioxidant power (FRAP) method and cupric reducing antioxidant capacity (CUPRAC) method were carried out for determination of antioxidant effects of compounds. The antioxidant activity of the compounds were compared with the standard antioxidants butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). Fe, Ni and Cu complexes exhibited more scavenging activity than BHT. All compounds exhibit lower ferric reducing activity than BHA and BHT. Fe complex, Ni complex and the ligand have more antioxidant capacity than corresponding to BHT according to CUPRAC method. These assays showed that all compounds researched can use as synthetic antioxidants. Antibacterial effects of Schiff base and its metal complexes were investigated by agar disc diffusion method. Antibacterial studies of the compounds were achieved against some gram-positive and gram-negative bacteria. Enterococcus faecium, Pseudomonas aeroginosa, Klebsiella pneumoniae and Escherichia coli were used as bacterial strains. The beneficial datas were acquired.