Affiliation:
1. UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE
2. DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY, LVIV, UKRAINE
Abstract
The aim: Evaluate the expediency of using different methods of treatment for patients with acute purulent-odontogenic inflammatory processes in both the main and control groups. This assessment will be based on various indicators of non-specific immunity.
Materials and methods: This study involved the evaluation of the humoral component of nonspecific immunity in 114 patients. We assessed changes in total protein and its fractions, C-reactive protein (CRP), lysozyme, and immunoglobulins (A, M, and G) during three distinct time intervals: 1-3 days, 5-7 days, and 8-14 days after treatment initiation. Statistical analysis was conducted using Statistica 10.0 (StatSoft, Inc., USA) and Microsoft Office Excel 2010.
Results: At different postoperative follow-up periods, a significant improvement in humoral nonspecific immunity indicators (p>0.05) was observed when comparing patients treated with and without platelet-rich plasma. This improvement is expected to enhance reparative processes and expedite recovery.
Conclusions: The incorporation of platelet-rich plasma, immunocorrective, and adaptogenic therapy into the comprehensive treatment of acute purulent odontogenic inflammatory processes in the maxillofacial region not only leads to pronounced and enduring positive outcomes but also results in substantial improvements, including the potential normalization of key humoral and cellular factors associated with innate immunity.
Reference14 articles.
1. 1. Olsen I, van Winkelhoff Acute focal infections of dental origin. A J.Periodontol 2000. 2014;65 (1):178-89. doi: 10.1111/prd.12018.
2. 2. Malanchuk V, Sidoryako A, Vardzhapetian S Modern treatment methods of phlegmon in the maxillo-facial area and neck. Georgian Med News. 2019;(294):57-61.
3. 3. Taub D, Yampolsky A, Diecidue R, Gold L. Controversies in the Management of Oral and Maxillofacial Infections. Oral Maxillofac Surg Clin North Am. 2017;29 (4):465-473. doi: 10.1016/j.coms.2017.06.004.
4. 4. Greenstein G, Greenstein B Clinical management of acute orofacial infections. Compend Contin Educ Dent. 2015;36 (2):96-103; quiz 104,114.
5. 5. Klitynska OV, Layosh NV, Zorivchak TI et al. Local anesthesia in childrens dental receptions. Problems of clinical pediatrics. 2021; 4 (54): 77–80. doi: 10.24144/1998-6475.2021.54.77–80.