THE METHOD OF ATOMIC FORCE MICROSCOPY AS A POSSIBLE TOOL FOR TESTING THE BIOCOMPATIBILITY OF IMPLANTS IN TRAUMATOLOGY AND ORTHOPEDICS PRACTICE

Abstract

The aim: To establish the possibility of using the atomic force microscope (AFM) to predict the body’s reaction to the implant. Materials and methods: A total of 32 patients, 22 men and 10 women, the average age of the patients was 55±6 years, were included in the study. They performed pre- and post-operative testing of the biocompatibility of orthopedic implant materials with the patient’s body with the help of AFM. Results: According to the research, an increase in pro-inflammatory factors was found, which may indicate a constant inflammatory process, which is probably related to the presence of the implant. Conclusions: On the basis of atomic force spectroscopy, an express method of testing biomaterials for compatibility with the body of a specific recipient and studying the effect of the reactions of recipient tissues on the surface of various implants has been developed. The obtained results can be useful in planning further clinical studies.