CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, without an increase in neo-angiogenesis

Author:

Capparelli Claudia123,Chiavarina Barbara12,Whitaker-Menezes Diana12,Pestell Timothy G.12,Pestell Richard G.124,Hulit James5,Andò Sebastiano3,Howell Anthony5,Martinez-Outschoorn Ubaldo E.124,Sotgia Federica125,Lisanti Michael P.1245

Affiliation:

1. The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA

2. Departments of Stem Cell Biology & Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA

3. Department of Pharmaco-Biology and Faculty of Pharmacy; University of Calabria; Arcavacata di Rende, Cosenza, Italy

4. Department of Medical Oncology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA

5. Manchester Breast Centre & Breakthrough Breast Cancer Research Unit; Paterson Institute for Cancer Research; School of Cancer, Enabling Sciences and Technology; Manchester Academic Health Science Centre; University of Manchester; Manchester, UK

Publisher

Informa UK Limited

Subject

Cell Biology,Developmental Biology,Molecular Biology

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