PD-L1 co-stimulation, ligand-induced TCR down-modulation and anti-tumor immunotherapy
Author:
Publisher
Informa UK Limited
Subject
Oncology,Immunology,Immunology and Allergy
Link
http://www.tandfonline.com/doi/pdf/10.4161/onci.1.1.17824
Reference10 articles.
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2. PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells;Latchman;Proc Natl Acad Sci U S A,2004
3. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation;Freeman;J Exp Med,2000
4. Karwacz K, Bricogne C, Macdonald D, Arce F, Bennett C, Collins M, et al. PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+ T cells. EMBO Mol Med 2011; doi:10.1002/emmm.201100165.
5. Triggering the TCR complex causes the downregulation of nonengaged receptors by a signal transduction-dependent mechanism;San José;Immunity,2000
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