Addition of N-terminal peptide sequences activates the oncogenic and signaling potentials of the catalytic subunit p110α of phosphoinositide-3-kinase
Author:
Affiliation:
1. The Scripps Research Institute; Department of Molecular and Experimental Medicine; La Jolla, CA USA
2. Astex Therapeutics Ltd; Cambridge, UK
3. Ambrx Inc.; La Jolla, CA USA
Publisher
Informa UK Limited
Subject
Cell Biology,Developmental Biology,Molecular Biology
Link
https://www.tandfonline.com/doi/pdf/10.4161/cc.10.21.17920
Reference49 articles.
1. Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit
2. The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex
3. A biochemical mechanism for the oncogenic potential of the p110 catalytic subunit of phosphoinositide 3-kinase
4. The p110 isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110
5. Differential Sensitivity of Phosphatidylinositol 3-Kinase p110γ to Isoforms of G Protein βγ Dimers
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