Glanzmann Thrombasthenia: A Case Report of a Rare Inherited Coagulation Disorder Presenting with Traumatic Head Injury

Author:

Chakati Vishal1,Bukka Durga Prasad1,Erigaisi Srinivas Rao2,Anchuri Shyam Sunder1

Affiliation:

1. Department of Pharmacy Practice, Balaji Institute of Pharmaceutical Sciences, Telangana, India

2. Srinivasa Pinnacle Neuro & Multispeciality Hospital, Hanmakonda, India

Abstract

This case study deals with a 32-year-old Indian male patient who presented with a traumatic head injury in the hospital, experienced uncontrolled bleeding after conducting surgery, and was eventually diagnosed with Glanzmann thrombasthenia. Glanzmann thrombasthenia is a rare hereditary blood clotting disorder characterised by a lack of platelet aggregation due to the absence of platelet glycoprotein IIb/IIIa. This occurrence is generally triggered by consanguineous marriages and is apparent in approximately one in one million people. Education and raising awareness about consanguinity in communities may help to reduce challenging, unusual genetic diseases.

Publisher

European Medical Group

Reference20 articles.

1. Sebastiano C et al. Glanzmann's thrombasthenia: report of a case and review of the literature. Int J Clin Exp Pathol. 2010;3(4):443-7.

2. Mitchell WB, French DL. Glanzmann Thrombasthenia. In: The NORD Guide to Rare Disorders, (2003), Philadelphia: Lippincott, Williams and Wilkins, pp. 383-4.

3. Poon MC. Clinical use of recombinant human activated factor VII (rFVIIa) in the prevention and treatment of bleeding episodes in patients with Glanzmann thrombasthenia. Vasc Health Risk Manag. 2007;3(5):655-64.

4. Tholouli E et al. Acquired Glanzmann's thrombasthenia without thrombocytopenia: a severe acquired autoimmune bleeding disorder. Br J Haematol. 2004;127(2):209-13.

5. Iqbal I et al. Glanzmann thrombasthenia: a clinicopathological profile. J Coll Physicians Surg Pak. 2016;26(8):647-50.

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