Idebenone Treatment for Leber Hereditary Optic Neuropathy: Time to Clinically Relevant Recovery in the LEROS Study

Author:

Morgia Chiara1,Klopstock Thomas2,Yu-Wai-Man Patrick3

Affiliation:

1. IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy;Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy

2. . Friedrich Baur Institute at the Department of Neurology, University Hospital of Ludwig-Maximilians-Universität München, Munich, Germany

3. John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, UK;MRC Mitochondrial Biology Unit, Department of Clinical Neurosciences, University of Cambridge, UK; Cambridge Eye Unit, Addenbrooke’s Hospital, Cambridge University Hospitals, UK;Moorfields Eye Hospital NHS Foundation Trust, London, UK; Institute of Ophthalmology, University College London, UK

Publisher

European Medical Group

Reference5 articles.

1. Carelli V et al. International consensus statement on the clinical and therapeutic management of Leber hereditary optic neuropathy. J. Neuroophthalmol. 2017;37(4)371-81

2. Klopstock T et al. A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy. Brain. 2011;134(9)2677-86.

3. Catarino CB et al. Real-world clinical experience with idebenone in the treatment of Leber hereditary optic neuropathy. J Neuroophthalmol. 2020;40(3)558-65.

4. Yu-Wai-Man P et al. Therapeutic benefit of idebenone in patients with Leber hereditary optic neuropathy: The LEROS nonrandomized controlled trial. Cell Rep Med. 2024;5(3)101437.

5. La Morgia C et al. Idebenone treatment for Leber hereditary optic neuropathy; time to clinically relevant recovery in the LEROS study. Eur J Neurol. 2024;31:e16337.

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