Abstract
Prof D’Amore opened the symposium by highlighting that management of patients with relapsed or refractory aggressive B cell non-Hodgkin lymphoma (NHL) remains an unmet clinical need because of its poor prognosis and the lack of effective therapeutic options. He proceeded to introduce pixantrone, the first approved single-agent treatment for the management of aggressive NHL in the third or fourth lines. Dr Lugtenburg then outlined the current treatment landscape for diffuse large B cell lymphoma (DLBCL). Dr Pettengell presented clinical evidence from the PIX301 study, explaining the clinical evidence behind the regulatory approvals for the use of pixantrone in relapsed or refractory aggressive NHL as well as discussing the mechanism of action of pixantrone. Prof Zinzani discussed the use of pixantrone as a new therapeutic option in clinical practice, and was followed by Prof Cordoba, who presented two clinical cases of patients treated with pixantrone. The symposium concluded with a panel discussion.