Epigenetics of Diabetic Nephropathy: From Biology to Therapeutics-Reference-Cited by-同舟云学术

Epigenetics of Diabetic Nephropathy: From Biology to Therapeutics

Published:2020-03-31 Issue: Volume: Page:48-57
ISSN:2397-6764
Container-title:European Medical Journal
language:
Short-container-title:EMJ

Author:

Al-Hasani Keith¹,Khurana Ishant¹,Farhat Theresa²,Eid Assaad²,El-Osta Assam³

Affiliation:

1. Department of Diabetes, Epigenetics in Human Health and Disease Laboratory, Monash University, Melbourne, Australia

2. Department of Anatomy, Cell Biology and Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

3. Department of Diabetes, Epigenetics in Human Health and Disease Laboratory, Monash University, Melbourne, Australia; Department of Clinical Pathology, The University of Melbourne, Victoria, Australia; Faculty of Health, Department of Technology, Biomedical Laboratory Science, University College Copenhagen, Copenhagen, Denmark; Hong Kong Institute of Diabetes and Obesity, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong

Abstract

Diabetic nephropathy (DN) is a lethal microvascular complication associated with Type 1 and Type 2 diabetes mellitus, and is the leading single cause of end-stage renal disease. Although genetic influences are important, epigenetic mechanisms have been implicated in several aspects of the disease. The current therapeutic methods to treat DN are limited to slowing disease progression without repair and regeneration of the damaged nephrons. Replacing dying or diseased kidney cells with new nephrons is an attractive strategy. This review considers the genetic and epigenetic control of nephrogenesis, together with the epigenetic mechanisms that accompany kidney development and recent advances in induced reprogramming and kidney cell regeneration in the context of DN.

Publisher

European Medical Group

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