Radiosynovectomy for hemophilic arthropathies. Analysis of opportunities and prospects-Reference-Cited by-同舟云学术

Radiosynovectomy for hemophilic arthropathies. Analysis of opportunities and prospects

Published:2024-08-19 Issue:2 Volume:69 Page:226-235
ISSN:2411-3042
Container-title:Russian journal of hematology and transfusiology
language:
Short-container-title:Gematologiâ i transfuziologiâ

Author:

Krylov V. V.¹^ORCID,Zheleznov A. A.¹^ORCID,Zorenko V. Yu.²^ORCID,Kim A. Yu.²^ORCID

Affiliation:

1. Tsyb Medical Radiological Research Centre — branch of the National Medical Research Radiological Centrе

2. National Medical Research Center for Hematology

Abstract

Introduction. A characteristic symptom of hemophilia is joint hemorrhage (hemarthroses).Aim: to evaluate the possibilities of radiosynovectomy in hemophilic arthropathies.Main findings. Radiosynovectomy (RSE) or radiosynoviorthesis (RSO) is a technique that achieves a long-lasting effect in chronic synovitis and hemophilic arthropathy. It consists of intra-articular injection of radiopharmaceuticals (RFLP) in the form of colloidal solutions, macroaggregates or microspheres containing radioactive isotopes, which are rapidly phagocytized by the covering cells of the synovial membrane. After such capture, the synovial sheath is subjected to intensive “internal” irradiation, which results in superficial fibrosis of synovial tissue and persistent suppression of joint inflammation.

Publisher

National Medical Research Center of Hematology of the Ministry of Health of the Russian Federation

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