Stroke After Coronary Bypass Surgery Is Mainly Related to Diffuse Atherosclerotic Disease

Abstract

<p><b>Objective:</b> This study aims to investigate the risk factors for postoperative stroke and analysis of outcome after coronary bypass surgery with cardiopulmonary bypass.</p><p><b>Methods:</b> Between 1999 and 2008, 3248 consecutive patients who underwent isolated coronary surgery with cardiopulmonary bypass were prospectively enrolled in the study. Demographic and perioperative data were analyzed. Postoperative stroke was defined as severe adverse neurological events including permanent deficits or cerebral lesions with radiological demonstration of cerebral infarction within the first postoperative month.</p><p><b>Results:</b> In total, 32 patients (0.9%) were determined with stroke. Univariate risk factors for postoperative stroke were determined as preoperative unstable angina (<i>P</i> = .006), Canadian Class of Angina (CCA) ? 3 (<i>P</i> = .001), preoperative creatinin level >1.2 mg/dL (<i>P</i> = .001), left main coronary artery disease (<i>P</i> = .04), chronic obstructive lung disease (<i>P</i> = .04), peripheral arterial disease (<i>P</i> < .001), New York Heart Association (NYHA) Class ? 3 (<i>P</i> = .004), preoperative renal insufficiency (<i>P</i> = .001), age > 65 years (<i>P</i> = .04), preoperative hypothyroidism (<i>P</i> = .02), postoperative low cardiac output state (<i>P</i> < .001), severe coronary artery disease requiring distal anastomosis ? 4 (<i>P</i> = .05), non-elective operation (<i>P</i> = .02), and body mass index ? 25 (<i>P</i> = .02). Multivariate analysis revealed peripheral arterial disease (odds ratio [OR], 5.2; 95% confidence interval [CI], 1.9-14.0; <i>P</i> = .001), severe coronary artery disease (OR, 3.1; 95% CI, 1.1-8.5; <i>P</i> = .02), and postoperative low cardiac output state (OR, 5.1; 95% CI, 1.4-18.2; <i>P</i> = .01) as the independent risk factors.</p><p><b>Conclusions:</b> Stroke after coronary bypass surgery with cardiopulmonary bypass is mainly related to diffuse atherosclerotic disease.</p>