Notch and the Awesome Power of Genetics-Reference-Cited by-同舟云学术

Notch and the Awesome Power of Genetics

Published:2012-07-01 Issue:3 Volume:191 Page:655-669
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Greenwald Iva¹

Affiliation:

1. Department of Biochemistry and Molecular Biophysics, Department of Genetics and Development, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032

Abstract

Abstract Notch is a receptor that mediates cell–cell interactions in animal development, and aberrations in Notch signal transduction can cause cancer and other human diseases. Here, I describe the major advances in the Notch field from the identification of the first mutant in Drosophila almost a century ago through the elucidation of the unusual mechanism of signal transduction a little over a decade ago. As an essay for the GENETICS Perspectives series, it is my personal and critical commentary as well as an historical account of discovery.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/191/3/655/42121594/genetics0655.pdf

Reference133 articles.

1. Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster;Artavanis-Tsakonas;Proc. Natl. Acad. Sci. USA,1983

2. Notch signaling: cell fate control and signal integration in development;Artavanis-Tsakonas;Science,1999

3. glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans;Austin;Cell,1987

4. Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity;Bailey;Genes Dev.,1995

5. Molecular genetics of the bithorax complex in Drosophila melanogaster;Bender;Science,1983

Cited by 56 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells;Nature Communications;2024-06-08

2. Notch Signaling and Lateral Specification;Reference Module in Life Sciences;2024

3. Mechanisms of lineage specification in Caenorhabditis elegans;GENETICS;2023-10-17

4. NOTCH Signaling Pathway: Occurrence, Mechanism, and NOTCH-Directed Therapy for the Management of Cancer;Cancer Biotherapy and Radiopharmaceuticals;2023-10-05

5. The take-off of Drosophila research in 1930–1950s Edinburgh;Journal of the Royal College of Physicians of Edinburgh;2023-03-16