Affiliation:
1. Fred Hutchinson Cancer Research Center, Seattle, Washington 98109
2. Department of Biochemistry, University of Washington, Seattle, Washington 98195
Abstract
Abstract
Here we review recent advances in understanding the regulation of mRNA synthesis in Saccharomyces cerevisiae. Many fundamental gene regulatory mechanisms have been conserved in all eukaryotes, and budding yeast has been at the forefront in the discovery and dissection of these conserved mechanisms. Topics covered include upstream activation sequence and promoter structure, transcription factor classification, and examples of regulated transcription factor activity. We also examine advances in understanding the RNA polymerase II transcription machinery, conserved coactivator complexes, transcription activation domains, and the cooperation of these factors in gene regulatory mechanisms.
Publisher
Oxford University Press (OUP)
Cited by
274 articles.
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