A Novel Role of the N Terminus of Budding Yeast Histone H3 Variant Cse4 in Ubiquitin-Mediated Proteolysis-Reference-Cited by-同舟云学术

A Novel Role of the N Terminus of Budding Yeast Histone H3 Variant Cse4 in Ubiquitin-Mediated Proteolysis

Published:2013-06-01 Issue:2 Volume:194 Page:513-518
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Au Wei Chun¹,Dawson Anthony R¹,Rawson David W¹,Taylor Sara B¹,Baker Richard E²,Basrai Munira A¹

Affiliation:

1. Genetics Branch Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20889

2. Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts 01655

Abstract

Abstract Regulating levels of centromeric histone H3 (CenH3) variant is crucial for genome stability. Interaction of Psh1, an E3 ligase, with the C terminus of Cse4 has been shown to contribute to its proteolysis. Here, we demonstrate a role for ubiquitination of the N terminus of Cse4 in regulating Cse4 proteolysis for faithful chromosome segregation and a role for Doa1 in ubiquitination of Cse4.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/194/2/513/42118446/genetics0513.pdf

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