Mapping Novel Traits by Array-Assisted Bulk Segregant Analysis in Saccharomyces cerevisiae-Reference-Cited by-同舟云学术

Mapping Novel Traits by Array-Assisted Bulk Segregant Analysis in Saccharomyces cerevisiae

Published:2006-07-01 Issue:3 Volume:173 Page:1813-1816
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Brauer Matthew J¹²,Christianson Cheryl M²,Pai Dave A²,Dunham Maitreya J²

Affiliation:

1. Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 and

2. Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544

Abstract

Abstract We demonstrate a new method, microarray-assisted bulk segregant analysis, for mapping traits in yeast by genotyping pooled segregants. We apply a probabilistic model to the progeny of a single cross and as little as two microarray hybridizations to reliably map an auxotrophic marker, a Mendelian trait, and a major-effect quantitative trait locus.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/173/3/1813/42069136/genetics1813.pdf

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