Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control-Reference-Cited by-同舟云学术

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

Published:2011-12-01 Issue:4 Volume:189 Page:1177-1201
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Loewith Robbie¹,Hall Michael N²

Affiliation:

1. Department of Molecular Biology and National Centers of Competence in Research and Frontiers in Genetics and Chemical Biology, University of Geneva, Geneva, CH-1211, Switzerland

2. Biozentrum, University of Basel, Basel CH-4056, Switzerland

Abstract

Abstract TOR (Target Of Rapamycin) is a highly conserved protein kinase that is important in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive, central controller of cell growth and aging. In clinical biology, TOR is implicated in many diseases and is the target of the drug rapamycin used in three different therapeutic areas. The yeast Saccharomyces cerevisiae has played a prominent role in both the discovery of TOR and the elucidation of its function. Here we review the TOR signaling network in S. cerevisiae.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/189/4/1177/42139317/genetics1177.pdf

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