Genome-Wide Copy Number Variant Analysis in Inbred Chickens Lines With Different Susceptibility to Marek’s Disease-Reference-Cited by-同舟云学术

Genome-Wide Copy Number Variant Analysis in Inbred Chickens Lines With Different Susceptibility to Marek’s Disease

Published:2013-02-01 Issue:2 Volume:3 Page:217-223
ISSN:2160-1836
Container-title:G3 Genes|Genomes|Genetics
language:en
Short-container-title:

Author:

Luo Juan¹,Yu Ying¹,Mitra Apratim¹,Chang Shuang²,Zhang Huanmin²,Liu George³,Yang Ning⁴,Song Jiuzhou¹¹

Affiliation:

1. Department of Animal & Avian Sciences, University of Maryland, College Park, Maryland 20742

2. United States Department of Agriculture-Agriculture Research Service (ARS), Avian Disease and Oncology Laboratory, East Lansing, Michigan 48823

3. Bovine Functional Genomic Laboratory, Animal and Natural Resources Institute, United States Department of Agriculture-Agricultural Research Service, Beltsville, Maryland 20705

4. Department of Animal Breeding and Genetics, College of Animal Sciences, China Agricultural University, Beijing, 100193, People's Republic of China

Abstract

Abstract Breeding of genetically resistant chickens to Marek’s disease (MD) is a vital strategy to poultry health. To find the markers underlying the genetic resistance to MD, copy number variation (CNV) was examined in inbred MD-resistant and -susceptible chicken lines. A total of 45 CNVs were found in four lines of chickens, and 28 were potentially involved in immune response and cell proliferation, etc. Importantly, two CNVs related with MD resistance were transmitted to descendent recombinant congenic lines that differ in susceptibility to MD. Our findings may lead to better strategies for genetic improvement of disease resistance in poultry.

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology

Link

http://academic.oup.com/g3journal/article-pdf/3/2/217/37074385/g3journal0217.pdf

Reference40 articles.

1. A review of the development of chicken lines to resolve genes determining resistance to diseases;Bacon;Poult. Sci.,2000

2. BAALC, a novel marker of human hematopoietic progenitor cells;Baldus;Exp. Hematol.,2003

3. Copy number variants and genetic traits: closer to the resolution of phenotypic to genotypic variability;Beckmann;Nat. Rev. Genet.,2007

4. Marek’s disease—a model for herpesvirus oncology;Calnek;Crit. Rev. Microbiol.,1986

5. Pathogenesis of Marek’s disease virus infection;Calnek;Curr. Top. Microbiol. Immunol.,2001

Cited by 34 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. circRUNX2.2, highly expressed in Marek's disease tumor tissues, functions in cis to regulate parental gene RUNX2 expression;Poultry Science;2024-10

2. Fitness consequences of structural variation inferred from a House Finch pangenome;2024-05-17

3. Epigenetic Factor MicroRNAs Likely Mediate Vaccine Protection Efficacy against Lymphomas in Response to Tumor Virus Infection in Chickens through Target Gene Involved Signaling Pathways;Veterinary Sciences;2024-03-22

4. Identification of the genetic characteristics of copy number variations in experimental specific pathogen-free ducks using whole-genome resequencing;BMC Genomics;2024-01-02

5. Contribution of the TCRβ Repertoire to Marek’s Disease Genetic Resistance in the Chicken;Viruses;2023-02-22