Preparation and characterization of ketoprofen and pentoxifylline agents based layered double hydroxides-chitosan nanohybride and its releasing control

Abstract

The suggested research focused on the construction of a nanocomposite containing organic-inorganic materials as a pharmaceutical shipper to provide a regulated and preserved release of Ketoprofen and Pentoxifylline to reduce its hazards. The study examined the kinetics and the adsorption isotherms of these agents on layered double hydroxides, chitosan, and chitosan-layered double hydroxide nanocomposites that were prepared chemically and identified by high resolution transmission electron microscope, X-ray diffraction, and Fourier transformation Infra-red Spectroscopy. The results showed controlled and continued free through layer hydroxides, chitosan and chitosan-layered hydroxides. Langmuir was the best for illustrating and fitting the sorption equilibrium of Ketoprofen and Pentoxifylline onto the layered double hydroxides, counteracting Freundlich in Chitosan and Chitosan-layered double hydroxide adsorbents. Chitosanlayered double hydroxides, layered double hydroxides, and Chitosan achieved complete release of Pentoxifylline only. Furthermore, Ketoprofen release from chitosan particles was first order, whereas Pentoxifylline release from chitosan-layered double hydroxide complex was zero order. As a final point, the tested nanocarriers restricted the release of Ketoprofen and Pentoxifylline meticulously.