Author:
Guo H., ,Fan L.,Ding L.,Hou H. L.,Yang W. Q.,Fan S. J., , , , ,
Abstract
γ-PGA-PAE nanomaterials were prepared by spontaneous assembly of γ-PGA through condensation reaction, and preparation process of nanomaterials was optimized. HCPT/PGA-PAE nanospheres were prepared by using 10-hydroxycamptothecin as embedding drug, and the nanospheres prepared under the optimal conditions were characterized. The results showed that γ-PGA-PAE nanomaterials were successfully prepared with spherical shape and uniform distribution. HCPT/PGA-PAE nanospheres had high encapsulation rate and drug loading. The optimization of the processing conditions of nanomaterials by response surface method (RSM) is a feasible method to improve the utilization rate of γ-PGA, which provides a theoretical basis for the synthesis of nanomaterials in the future
Publisher
Virtual Company of Physics
Subject
Physical and Theoretical Chemistry,Condensed Matter Physics,General Materials Science,Biomedical Engineering,Atomic and Molecular Physics, and Optics,Structural Biology
Cited by
1 articles.
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