Evaluation of Plasma Total Thiol Levels in Patients with Carbon Monoxide Poisoning in the Emergency Department

Author:

DELİCE Orhan1ORCID,DAŞ Murat2ORCID,KURTOĞLU ÇELİK Gülhan3ORCID,ŞAHİN KAVAKLI Havva3ORCID,NEŞELİOĞLU Salim4ORCID,IŞIKOĞLU HATIL Semra5ORCID

Affiliation:

1. SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ERZURUM BÖLGE SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ

2. ÇANAKKALE ONSEKİZ MART ÜNİVERSİTESİ, TIP FAKÜLTESİ

3. SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, ACİL TIP ANABİLİM DALI

4. ANKARA YILDIRIM BEYAZIT ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOKİMYA ANABİLİM DALI

5. SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA DIŞKAPI YILDIRIM BEYAZIT SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ

Abstract

Objective: The study aimed to measure the levels of total thiol, an antioxidant parameter, in patients who presented to the emergency department (ED) with carbon monoxide (CO) poisoning under normobaric oxygen therapy (NBOT), evaluate the time-dependent changes in total thiol levels within the first 6 hours, and examine the course of antioxidants in CO poisoning. Materials and Method: The study population consisted of 85 patients diagnosed with CO poisoning in the ED and 50 volunteers. Total thiol level was measured in the study group at the admission (T0), first (T1) and sixth hour (T6). Carboxyhemoglobin levels, cardiac markers, electrocardiography, and routinely requested tests were investigated in patients with poisoning. The total thiol level was measured in the volunteer group. Results: There was a significant decrease in total thiol mean levels between T0 and T1 (p

Publisher

Eurasian Journal of Toxicology, Emergency Physicians Association of Turkey

Subject

General Medicine

Reference15 articles.

1. Maloney G. Carbon Monoxide Poisoning. In: Tintinalli JE. Stapczynski JS. Ma OJ,Cline DM, Cydulka RK, Meckler GD; Emergency Medicine. Mc Graw-Hill New York 2011; p.1410- 1413.

2. Aslan S, Erol MK, Karcioglu O, Meral M, Cakir Z, Katirci Y. The investigation of ischemic myocardial damage in patients with carbon monoxide poisoning. Anadolu Kardiyol Derg. 2005; 5: 189-93

3. Raub JA. Health effects of exposure to ambient carbon monoxide. Global Change Science. 1999;1:331–351.

4. Satran D, Henry CR, Adkinson C, Nıcholson CI, Bracha Y, Henry TD. Cardiovascular Menifestations of moderate to severe carbon monoxide poisoning. J Am Coll Cardiol. 2005;45(9):1513-16.

5. Kao LW, Nanagas KA. Carbon monoxide poisoning. Emerg Med Clin North Am. 2004; 22: 985-1018.

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