Gut microbiota from Mexican patients with metabolic syndrome and HIV infection: An inflammatory profile

Author:

Amador-Lara Fernando12ORCID,Andrade-Villanueva Jaime F.12ORCID,Vega-Magaña Natali34ORCID,Peña-Rodríguez Marcela5ORCID,Alvarez-Zavala Monserrat12ORCID,Sanchez-Reyes Karina12ORCID,Toscano-Piña Marcela1ORCID,Peregrina-Lucano Alejandro A.6ORCID,del Toro-Arreola Susana5ORCID,González-Hernández Luz A.12ORCID,Bueno-Topete Miriam R.5ORCID

Affiliation:

1. Unidad de VIH, Hospital Civil de Guadalajara "Fray Antonio Alcalde" Guadalajara Mexico

2. Instituto de Investigación en Inmunodeficiencias y VIH (InIVIH), Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud Universidad de Guadalajara Guadalajara Mexico

3. Laboratorio de Diagnóstico de Enfermedades Emergentes y Reemergentes (LaDEER), Departamento de Microbiología y Patología, Centro Universitario de Ciencias de la Salud Universidad de Guadalajara Guadalajara Mexico

4. Instituto de Investigación en Ciencias Biomédicas (IICB), Departamento de Clínicas Médicas Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara Guadalajara Mexico

5. Instituto de Investigación en Enfermedades Crónico-Degenerativas (IECD), Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud Universidad de Guadalajara Guadalajara Mexico

6. Departamento de Farmacobiología, Centro Universitario de Ciencias Exactas e Ingenierías Universidad de Guadalajara Guadalajara Mexico

Abstract

Abstract Aim A remarkable increase in metabolic syndrome (MetS) has occurred in HIV-infected subjects. Gut dysbiosis is involved in the pathogenesis of metabolic disorders. Therefore, the aim is to explore the profile of the gut microbiota in Mexican population with HIV infection and MetS. Methods and Results In all, 30 HIV-infected patients with MetS were compared to a group of 30 patients without MetS, treated with integrase inhibitors and undetectable viral load were included in the study. Stool samples were analysed by 16S rRNA next-generation sequencing. High-sensitivity C-reactive protein >3 mg L−1 and higher scores in cardiometabolic indices were associated with MetS. The group with MetS was characterized by a decrease in α-diversity, higher abundance of Enterobacteriaceae and Prevotella, as well as a dramatic decrease in bacteria producing short-chain fatty acids. Prevotella negatively correlated with Akkermansia, Lactobacillus and Anaerostipes. Interestingly, the group without MetS presented higher abundance of Faecalibacterium, Ruminococcus, Anaerofilum, Oscillospira and Anaerostipes. Functional pathways related to energy metabolism and inflammation were increased in the group with MetS. Conclusions HIV-infected patients with MetS present a strong inflammatory microbiota profile; therefore, future strategies to balance intestinal dysbiosis should be implemented.

Funder

Universidad de Guadalajara

Publisher

Oxford University Press (OUP)

Subject

Applied Microbiology and Biotechnology,General Medicine,Biotechnology

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