Five‐ and 10‐year survival in extramammary Paget's disease: A focus on wide local excision

Abstract

AbstractAimThis study aimed to analyze extramammary Paget's disease (EMPD)‐specific survival, overall survival, and recurrence rate (RR) in patients with EMPD in South Korea, with a focus on wide local excision.MethodsWe retrospectively reviewed the medical records of patients with EMPD from 1993 to 2020 at Kyungpook National University Hospital. We determined the survival and RRs after wide local excision.ResultsA total of 95 patients (66 males and 29 females; mean age 67.4 years) were included. The 5‐year disease‐specific survival and overall survival were 91.8% and 79.3%, respectively, whereas the 10‐year rates were 81.6% and 64.7%, respectively. No significant sex differences were observed. Seventy‐five patients (78.9%) underwent wide local excision. Mucosal involvement and lymphadenopathy were identified as the significant prognostic factors of disease‐specific survival in multivariate analysis. The RR was 14.7% in patients who underwent wide local excision: seven local, two regional, and two distant metastases, with a mean recurrence‐free interval of 42.3 months.ConclusionBased on the survival and RRs obtained, surgical treatment of EMPD with wide local excision provides fair curative resection.Practitioner pointsWide local excision can be a feasible treatment option for extramammary Paget's disease.