Pharmacokinetics, metabolism and safety of deuterated L-DOPA (SD-1077)/carbidopa compared to L-DOPA/carbidopa following single oral dose administration in healthy subjects

Author:

Schneider Frank1ORCID,Erisson Lavi2,Beygi Hooman2,Bradbury Margaret3,Cohen-Barak Orit4,Grachev Igor D.5,Guzy Serge6,Loupe Pippa S.7,Levi Micha2,McDonald Mirna2,Savola Juha-Matti8,Papapetropoulos Spyros9,Tracewell William G.2,Velinova Maria10,Spiegelstein Ofer4

Affiliation:

1. Global Research and Development; Teva Pharmaceutical Industries; Berlin Germany

2. Global Research and Development; Teva Pharmaceutical Industries; West Chester PA USA

3. Formerly Global Research and Development Teva Pharmaceuticals; currently Prana Biotechnology; San Francisco CA USA

4. Global Research and Development; Teva Pharmaceutical Industries; Netanya Israel

5. Global Research and Development; Teva Pharmaceutical Industries; Malvern PA USA

6. Pop-Pharm Pharmacometrics Service; Albany CA USA

7. Global Research and Development; Teva Pharmaceutical Industries; Overland Park KS USA

8. Teva Pharmaceuticals International GmbH; Basel Switzerland

9. Massachusetts General Hospital; Boston MA USA

10. PRA Health Sciences; Early Development Services; Groningen the Netherlands

Funder

Teva Pharmaceutical Industries

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference36 articles.

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2. Priorities in Parkinson's disease research;Meissner;Nat Rev Drug Discov,2011

3. Time of loss of employment in Parkinson's disease;Schrag;Mov Disord,2006

4. Impact of newer pharmacological treatments on quality of life in patients with Parkinson's disease;Gallagher;CNS Drugs,2008

5. A comparison of the effects of reversible and irreversible inhibitors of aromatic L-amino acid decarboxylase on the half-life and other pharmacokinetic parameters of oral L-3,4-dihydroxyphenylalanine;Huebert;Drug Metab Dispos,1983

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