Lack of GPR40/FFAR1does not induce diabetes even under insulin resistance condition-Reference-Cited by-同舟云学术

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Lack of GPR40/FFAR1does not induce diabetes even under insulin resistance condition

Published:2013-02-06 Issue:6 Volume:15 Page:538-545
ISSN:1462-8902
Container-title:Diabetes, Obesity and Metabolism
language:en
Short-container-title:Diabetes Obes Metab

Author:

Matsuda-Nagasumi K.¹,Takami-Esaki R.²,Iwachidow K.²,Yasuhara Y.¹,Tanaka H.²,Ogi K.³,Nakata M.²,Yano T.²,Hinuma S.⁴,Taketomi S.⁴,Odaka H.⁴,Kaisho Y.⁵

Affiliation:

1. Metabolic Disease Drug Discovery Unit; Takeda Pharmaceutical Company Limited; Kanagawa Japan

2. Biomolecular Research Laboratories; Takeda Pharmaceutical Company Limited; Kanagawa Japan

3. Advanced Science Research Laboratories; Takeda Pharmaceutical Company Limited; Kanagawa Japan

4. Pharmaceutical Research Division; Takeda Pharmaceutical Company Limited; Kanagawa Japan

5. General Manager Office; Takeda Pharmaceutical Company Limited; Kanagawa Japan

Publisher

Wiley

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/dom.12065/fullpdf

Reference36 articles.

1. Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion;Prentki;J Biol Chem,1992

2. Fatty acid metabolism and insulin secretion in pancreatic β cells;Yaney;Diabetologia,2003

3. Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40;Itoh;Nature,2003

4. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids;Briscoe;J Biol Chem,2003

5. Progress in methodology. Improved reporter gene assays used to identify ligands acting on orphan seven-transmembrane receptors;Kotarsky;Pharmacol Toxicol,2003

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1. Nutrient regulation of inflammatory signalling in obesity and vascular disease;Clinical Science;2021-07

2. GPR40 deficiency is associated with hepatic FAT/CD36 upregulation, steatosis, inflammation, and cell injury in C57BL/6 mice;American Journal of Physiology-Endocrinology and Metabolism;2021-01-01

3. Metformin Reduces Lipotoxicity-Induced Meta-Inflammation in β-Cells through the Activation of GPR40-PLC-IP3 Pathway;Journal of Diabetes Research;2019-12-19

4. Current status of GPR40/FFAR1 modulators in medicinal chemistry (2016–2019): a patent review;Expert Opinion on Therapeutic Patents;2019-12-02

5. GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve;PLOS ONE;2019-09-16

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