Can non-clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium-Reference-Cited by-同舟云学术

Can non-clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium

Published:2018-01-15 Issue:4 Volume:175 Page:606-617
ISSN:0007-1188
Container-title:British Journal of Pharmacology
language:en
Short-container-title:British Journal of Pharmacology

Author:

Park Eunjung¹,Gintant Gary A²,Bi Daoqin¹,Kozeli Devi¹,Pettit Syril D³,Pierson Jennifer B³^ORCID,Skinner Matthew⁴,Willard James¹,Wisialowski Todd⁵,Koerner John¹,Valentin Jean-Pierre⁶

Affiliation:

1. Center for Drug Evaluation and Research; US FDA; Silver Spring MD USA

2. Department of Integrative Pharmacology; AbbVie; North Chicago IL USA

3. HESI; Washington DC USA

4. Drug Safety and Metabolism; AstraZeneca; Macclesfield Cheshire UK

5. Drug Safety Research and Development; Pfizer; Groton CT USA

6. Non-Clinical Development; UCB-Biopharma SPRL; Braine-l'Alleud Belgium

Publisher

Wiley

Subject

Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bph.14101/fullpdf

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