Why Amyloid Is Still a Target for Alzheimer Disease Clinical Trials
Author:
Affiliation:
1. Department of Neurology; Washington University School of Medicine; St Louis Missouri
Publisher
Wiley
Subject
Geriatrics and Gerontology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/jgs.15829/fullpdf
Reference10 articles.
1. A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease;Karran;Ann Neurol,2014
2. Amyloid deposition as the central event in the aetiology of Alzheimer's disease;Hardy;Trends Pharmacol Sci,1991
3. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline;Jonsson;Nature,2012
4. Effects of age and amyloid deposition on Abeta dynamics in the human central nervous system;Huang;Arch Neurol,2012
5. Certified normal: Alzheimer's disease biomarkers and normative estimates of cognitive functioning;Hassenstab;Neurobiol Aging,2016
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1. Discoveries and future significance of research into amyloid-beta/α7-containing nicotinic acetylcholine receptor (nAChR) interactions;Pharmacological Research;2023-05
2. Design, synthesis and biological evaluation of light-driven on–off multitarget AChE and MAO-B inhibitors;RSC Medicinal Chemistry;2022
3. A Novel Compound YS-5-23 Exhibits Neuroprotective Effect by Reducing β-Site Amyloid Precursor Protein Cleaving Enzyme 1’s Expression and H2O2-Induced Cytotoxicity in SH-SY5Y Cells;Neurochemical Research;2020-06-18
4. Reply to: Why Amyloid Is Still a Target for Alzheimer's Disease;Journal of the American Geriatrics Society;2019-03-09
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