IgM rheumatoid factor in congenital syphilis: associations with clinical and laboratory findings-Reference-Cited by-同舟云学术

IgM rheumatoid factor in congenital syphilis: associations with clinical and laboratory findings

Published:1991-10 Issue:1 Volume:86 Page:43-48
ISSN:1365-2249
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

MEYER M P¹,BEATTY D W²

Affiliation:

1. Department of Clinical Science and Immunology, University of Cape Town, Cape Town, South Africa

2. Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa

Abstract

SUMMARY IgM rheumatoid factor (RF), measured by means of an ELISA, was detected in 92% of infants with congenital syphilis. Elevated levels were found to correlate with liver and renal involvement as well as the extent of the disease (P<0.05). In addition, levels of circulating immune complexes were closely related to the RF concentration (P<0.001). Following treatment of the infants both RF levels and VDRL titres declined at a similar rate (P<0.001). These findings indicated a close relationship between the disease process and IgM RF levels. It is postulated that IgM RF may add to immune complex deposition and exacerbate tissue damage in congenital syphilis.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/86/1/43/42214062/j.1365-2249.1991.tb05771.x.pdf

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