The decrease of regulatory T cells correlates with excessive activation and apoptosis of CD8+T cells in HIV-1-infected typical progressors, but not in long-term non-progressors

Author:

Jiao Yanmei,Fu JunLiang,Xing Shaojun,Fu Baoyun,Zhang Zheng,Shi Ming,Wang Xicheng,Zhang Jiyuan,Jin Lei,Kang Fubiao,Wu Hao,Wang Fu-Sheng

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference40 articles.

1. Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune system before CD4+ T helper cell depletion occurs;Miedema;J Clin Invest,1988

2. HIV preferentially infects HIV-specific CD4+ T cells;Douek;Nature,2002

3. Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression;Gougeon;J Immunol,1996

4. Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden;Muro-Cacho;J Immunol,1995

5. Presence of CD3+CD8+Bcl-2(low) lymphocytes undergoing apoptosis and activated macrophages in lymph nodes of HIV-1+ patients;Bofill;Am J Pathol,1995

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