Class 1HDACandHDAC6 inhibition inversely regulatesCD38 induction in myeloma cells via interferon‐α andATRA

Author:

Bat‐Erdene Ariunzaya1,Nakamura Shingen1ORCID,Oda Asuka1,Iwasa Masami1,Teramachi Jumpei12,Ashtar Mohannad3,Harada Takeshi1,Miki Hirokazu4,Tenshin Hirofumi13,Hiasa Masahiro13,Fujii Shiro1ORCID,Sogabe Kimiko1,Oura Masahiro1,Udaka Kengo1,Kagawa Kumiko1,Yoshida Sumiko1,Aihara Ken‐ichi1,Kurahashi Kiyoe1,Endo Itsuro1,Abe Masahiro1

Affiliation:

1. Department of Haematology, Endocrinology and Metabolism Institute of Biomedical Sciences Tokushima University Graduate School of Medicine TokushimaJapan

2. Department of Tissue Regeneration Tokushima University Graduate School of Oral Sciences TokushimaJapan

3. Department of Orthodontics and Dentofacial Orthopaedics Tokushima University Graduate School of Oral Sciences TokushimaJapan

4. Division of Transfusion Medicine and Cell Therapy Tokushima University Hospital Tokushima Japan

Funder

Ministry of Education, Culture, Sports, Science and Technology

Publisher

Wiley

Subject

Hematology

Reference9 articles.

1. Inhibition of Histone Deacetylase 6 Acetylates and Disrupts the Chaperone Function of Heat Shock Protein 90

2. Upregulation of CD38 Gene Expression in Leukemic B Cells by Interferon Types I and II

3. Human CD38, a leukocyte receptor and ectoenzyme, is a member of a novel eukaryotic gene family of nicotinamide adenine dinucleotide+‐converting enzymes: extensive structural homology with the genes for murine bone marrow stromal cell antigen 1 and aplysian ADP‐ribosyl cyclase;Ferrero E.;Journal of Immunology,1997

4. Panobinostat induces CD38 upregulation and augments the antimyeloma efficacy of daratumumab;Garcia‐Guerrero E.;Blood,2017

5. All-trans retinoic acid and interferon-α increase CD38 expression on adult T-cell leukemia cells and sensitize them to T cells bearing anti-CD38 chimeric antigen receptors

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