Longitudinal myelin content measures of slowly expanding lesions using 7T MRI in multiple sclerosis

Author:

Huerta Mina M.1,Conway Devon S.2ORCID,Planchon Sarah M.2ORCID,Thoomukuntla Bhaskar3,Se‐Hong Oh4ORCID,Sakaie Ken E.5ORCID,Ontaneda Daniel2ORCID,Nakamura Kunio3ORCID

Affiliation:

1. School of Medicine Case Western Reserve University Cleveland Ohio USA

2. Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute Cleveland Clinic Cleveland Ohio USA

3. Department of Biomedical Engineering Cleveland Clinic Cleveland Ohio USA

4. Department of Biomedical Engineering Hankuk University of Foreign Studies Yongin Republic of Korea

5. Imaging Institute Cleveland Clinic Cleveland Ohio USA

Abstract

AbstractBackground and PurposeSlowly expanding lesions (SELs) are thought to represent a subset of chronic active lesions and have been associated with clinical disability, severity, and disease progression. The purpose of this study was to characterize SELs using advanced magnetic resonance imaging (MRI) measures related to myelin and neurite density on 7 Tesla (T) MRI.MethodsThe study design was retrospective, longitudinal, observational cohort with multiple sclerosis (n = 15). Magnetom 7T scanner was used to acquire magnetization‐prepared 2 rapid acquisition gradient echo and advanced MRI including visualization of short transverse relaxation time component (ViSTa) for myelin, quantitative magnetization transfer (qMT) for myelin, and neurite orientation dispersion density imaging (NODDI). SELs were defined as lesions showing ≥12% of growth over 12 months on serial MRI. Comparisons of quantitative measures in SELs and non‐SELs were performed at baseline and over time. Statistical analyses included two‐sample t‐test, analysis of variance, and mixed‐effects linear model for MRI metrics between lesion types.ResultsA total of 1075 lesions were evaluated. Two hundred twenty‐four lesions (21%) were SELs, and 216 (96%) of the SELs were black holes. At baseline, compared to non‐SELs, SELs showed significantly lower ViSTa (1.38 vs. 1.53, p < .001) and qMT (2.47 vs. 2.97, p < .001) but not in NODDI measures (p > .27). Longitudinally, only ViSTa showed a greater loss when comparing SEL and non‐SEL (p = .03).ConclusionsSELs have a lower myelin content relative to non‐SELs without a difference in neurite measures. SELs showed a longitudinal decrease in apparent myelin water fraction reflecting greater tissue injury.

Publisher

Wiley

Reference47 articles.

1. Impact of diagnosis and early treatment on the course of multiple sclerosis;Noyes K;Am J Manag Care,2013

2. In vivo imaging of chronic active lesions in multiple sclerosis

3. Imaging chronic active lesions in multiple sclerosis: a consensus statement

4. Pathology of multiple sclerosis: where do we stand?;Popescu BFG;Continuum,2013

5. Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3