IL-23 Activated γδ T Cells Affect Th17 Cells and Regulatory T Cells by Secreting IL-21 in Children with Primary Nephrotic Syndrome

Author:

Zhang L.1,Yan J.1,Yang B.1,Zhang G.2,Wang M.2,Dong S.13,Liu W.1,Yang H.2ORCID,Li Q.2

Affiliation:

1. Ministry of Education; Key Laboratory of Child Development and Disorders; Key Laboratory of Pediatrics in Chongqing; Chongqing International Science and Technology Cooperation Center for Child Development and Disorders; Chongqing China

2. Department of Nephroimmunology; Children's Hospital; Chongqing Medical University; Chongqing China

3. The Central Laboratory of Children's Hospital; Chongqing Medical University; Chongqing China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Immunology,General Medicine

Reference37 articles.

1. Analysis of 1268 patients with chronic renal failure in childhood: a report from 91 hospitals in China from 1990 to 2002;Yang;Zhonghua Er Ke Za Zhi,2004

2. A humanized mouse model of idiopathic nephrotic syndrome suggests a pathogenic role for immature cells;Sellier-Leclerc;J Am Soc Nephrol,2007

3. Pathogenesis of lipoid nephrosis: a disorder of T-cell function;Shalhoub;Lancet,1974

4. The role of Th17/IL-17 in the pathogenesis of primary nephrotic syndrome in children;Wang;Kidney Blood Press Res,2013

5. T-cell dysfunction in minimal-change nephrotic syndrome of childhood;Fodor;Am J Dis Child,1982

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