Potential anti‐obesity effects of fucoidan from Malaysian brown seaweed (<i>Sargassum binderi</i>) by <i>in vivo</i> study-Reference-Cited by-同舟云学术

Potential anti‐obesity effects of fucoidan from Malaysian brown seaweed (Sargassum binderi) by in vivo study

Published:2024-03-29 Issue:5 Volume:59 Page:3402-3411
ISSN:0950-5423
Container-title:International Journal of Food Science & Technology
language:en
Short-container-title:Int J of Food Sci Tech

Author:

Din Nur Akmal Solehah¹²^ORCID,Ishak Ainaatul Asmaa'¹,Maarof Syahida³,Abdul Rahman Hafeedza¹⁴^ORCID,Sofian‐Seng Noor‐Soffalina¹⁴^ORCID,Mohd Razali Noorul Syuhada¹⁴,Lim Seng Joe¹⁴^ORCID,Wan Mustapha Wan Aida¹⁴

Affiliation:

1. Department of Food Science, Faculty of Science and Technology Universiti Kebangsaan Malaysia 43600 Bangi Selangor Malaysia

2. Faculty of Fisheries and Food Science Universiti Malaysia Terengganu 21030 Kuala Nerus Terengganu Malaysia

3. Nutrition and Food Safety Program, Food Technology Research Centre Malaysia Agriculture and Research Development Institute (MARDI) 43400 Serdang Selangor Malaysia

4. Innovation Centre for Confectionery Technology (MANIS), Faculty of Science and Technology Universiti Kebangsaan Malaysia 43600 Bangi Selangor Malaysia

Abstract

SummaryBrown seaweed is a natural source of fucoidan, a polysaccharide known for its remarkable bioactivities. This study investigated the anti‐obesity effects of fucoidan (Fsar) from Malaysian brown seaweed (Sargassum binderi) using Sprague Dawley rats. The rats were divided into four dietary groups, including normal diet (ND), high‐fat diet (HFD), HFD with orlistat (HFD‐O) and HFD with Fsar (HFD‐F) for 28 days. Results showed a significant (P < 0.05) 36% reduction in body weight gain and an 18% decrease in visceral fat mass in the HFD‐F group compared to the HFD group. Additionally, Fsar treatment also significantly (P < 0.05) reduced insulin (threefold) and leptin (1.3‐fold) levels in blood serum. Improvements in obesity‐related biomarkers by Fsar were observed with a 1.1–1.4‐fold decrease in serum lipid profiles of total cholesterol, triglycerides and low‐density lipoprotein (LDL), without causing kidney or liver toxicity. These findings highlight fucoidan's potential as an anti‐obesity, especially in the food and pharmaceutical industries.

Funder

Kementerian Sains, Teknologi dan Inovasi

Publisher

Wiley

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