Phase I studies of the safety, tolerability, pharmacokinetics, and pharmacodynamics of DS‐1211, a tissue‐nonspecific alkaline phosphatase inhibitor
Author:
Affiliation:
1. Daiichi Sankyo, Inc. Basking Ridge New Jersey USA
2. Daiichi Sankyo Co., Ltd. Tokyo Japan
3. Worldwide Clinical Trials San Antonio Texas USA
Publisher
Wiley
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/cts.13214
Reference26 articles.
1. Alkaline phosphatase: placental and tissue-nonspecific isoenzymes hydrolyze phosphoethanolamine, inorganic pyrophosphate, and pyridoxal 5'-phosphate. Substrate accumulation in carriers of hypophosphatasia corrects during pregnancy.
2. Mammalian Alkaline Phosphatases
3. Markedly increased circulating pyridoxal-5'-phosphate levels in hypophosphatasia. Alkaline phosphatase acts in vitamin B6 metabolism.
4. NT5EMutations and Arterial Calcifications
5. Alkaline Phosphatase and Hypophosphatasia
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1. The biochemistry of mineralizing extracellular vesicles. Part I: The role of phosphatases;Mineralizing Vesicles;2024
2. Anticalcification effects of DS-1211 in pseudoxanthoma elasticum mouse models and the role of tissue-nonspecific alkaline phosphatase in ABCC6-deficient ectopic calcification;Scientific Reports;2022-11-18
3. In Vitro and In Vivo Pharmacological Profiles of DS ‐1211, a Novel Potent, Selective, and Orally Bioavailable Tissue‐Nonspecific Alkaline Phosphatase Inhibitor;Journal of Bone and Mineral Research;2022-09-13
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