Affiliation:
1. Department of Experimental Immunology, Amsterdam Institute for Infection and Immunity Amsterdam University Medical Centers Amsterdam The Netherlands
2. Neuroimmunology Research Group Netherlands Institute for Neuroscience Amsterdam The Netherlands
3. Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory Amsterdam University Medical Centers Amsterdam The Netherlands
Abstract
AbstractGPR56/ADGRG1 is an adhesion G protein‐coupled receptor connected to brain development, haematopoiesis, male fertility, and tumorigenesis. Nevertheless, expression of GPR56 is not restricted to developmental processes. Studies over the last years have demonstrated a marked presence of GPR56 in human cytotoxic NK and T cells. Expression of GPR56 in these cells is driven by the transcription factor HOBIT, corresponds with the production of cytolytic mediators and the presence of CX3CR1 and CD57, indicates a state of terminal differentiation and cellular exhaustion, and disappears upon cellular activation. Functional studies indicate that GPR56 regulates cell migration and effector functions and thereby acts as an inhibitory immune checkpoint. We here discuss the current state of knowledge regarding GPR56 in cytotoxic lymphocytes.
Funder
Deutsche Forschungsgemeinschaft
Subject
Pharmacology,Toxicology,General Medicine
Cited by
5 articles.
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